Different compounds that might modify the glucose regulation in the central nervous system will be evaluated in healthy volunteers. Several examinations will be performed in order to get a detailed plan how these substances might work.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
10 mg / d for 5 days, orally
160 IU / d for 5 days, intranasal
320 mg / d for 5 days, orally
Dep. of Psychiatry and Psychotherapy, Central Institute of Mental Health
Mannheim, Baden-Wurttemberg, Germany
Clinical assessment with several psychopathological scores for self-assessment and peer evaluation (BPRS, PANSS, SIPS, CGI, MADRS, HAM-A, SCL-90-R)
Time frame: Seven days
Laboratory assessment (routine testing, "-omics", genetic analyses, endocannabinoid levels)
Time frame: Seven days
Diagnostics of the cerebrospinal fluid
Time frame: Seven days
fMRI scan of the brain
Time frame: Seven days
Regular evaluating of the subject's condition and ability to continue the study by CGI
Time frame: Seven days
Regular laboratory testing and ECG
Time frame: Seven days
Scales for the assessment of adverse events (UKU, SCL- 90-R)
Time frame: Seven days
(Numbers of) SAE and AE
Time frame: Seven days
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