Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy

Instituto do Cerebro de Brasilia20 enrolled

Overview

This research investigates the use of autologous bone marrow stem cells for the treatment of medically refractory temporal lobe epilepsy patients.

The aim of this study is to evaluate autologous bone marrow stem cells transplantation as a safe and potentially beneficial treatment for patients with temporal lobe refractory epilepsy. We are mainly evaluating seizure frequency, hippocampal volume an cognitive performance

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Epilepsy

Interventions

Stem cell transplantationPROCEDURE

Transplantations with autologous bone marrow mononuclear stem cells by selective posterior cerebral artery angiography

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: * temporal lobe medically refractory epilepsy patients with hippocampal atrophy Exclusion Criteria: * under 18 or over 65 years old patients * previous neurological surgery * other neurodegenerative diseases

Locations (1)

Instituto do Cerebro

Porto Alegre, Rio Grande do Sul, Brazil

Outcomes

Primary Outcomes

seizure frequency

Time frame: 6 months

Secondary Outcomes

adverse effects

Time frame: 6 months

hippocampal volume

Time frame: 6 months

cognitive performance

Time frame: 6 months

Data from ClinicalTrials.gov

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