The objective of this trial is to assess the clinical efficacy of the modified extract (depigmented and polymerized with glutaraldehyde) of the subcutaneous injection of Parietaria Judaica pollen in the treatment of patients affected by allergic rhinitis/rhinoconjunctivitis ( with or without episodic asthma) induced by hypersensitivity to grass pollen, evaluating the score regarding symptoms and consumption of the medication.
Immunotherapy is a specific treatment for allergic diseases. Unlike conventional pharmacological treatment, immunotherapy is the only treatment that could modify the natural course of allergic disease. This is a prospective double-blind placebo controlled study with two arms of treatment: placebo and active.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
153
Subcutaneous monthly treatment
Subcutaneous monthly treatment
H. Germans Trias i Pujol
Badalona, Barcelona, Spain
Hospital Viladecans
Barcelona, Barcelona, Spain
Hospital Vega Baja
Alicante, Orihuela, Spain
H. de sagunto
Sagunto, Sagunto, Spain
Symptoms score
Time frame: 2 years
Nasal Provocation test, Dose- response skin prick test, Quality of life questionnaire, visual scales, asthma symptom scores, Medication scores, adverse event and severity adverse event,unplanned healthcare resource utilization
Time frame: 2 years
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Hospital General de Onteniente
Ontinyent, Valencia, Spain
Hospital Luis Alcañiz
Xàtiva, Valencia, Spain
Hospital Marina Baixa
Alicante, Spain
Hospital de Castellón
Castellon, Spain
Hospital Reina Sofía
Murcia, Spain
Hospital Virgen de la Arrixaca
Murcia, Spain
...and 1 more locations