A Multi-center Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on Non-head Locations (Trunk and Extremities)

Inclusion Criteria: * Patient is male or female and at least 18 years of age. * Female patient must be of either: * Non-childbearing potential, post-menopausal, or there is a confirmed clinical history of sterility (e.g., the patient is without a uterus) * Childbearing potential, provided there are negative urine pregnancy test results prior to study treatment, to rule out pregnancy Exclusion Criteria * Cosmetic or therapeutic procedures within two weeks and within 2 cm of the selected treatment area. * Treatment with immunomodulators, interferon/ interferon inducers or systemic medications that suppress the immune system within 4 weeks. * Treatment with 5-FU, imiquimod, diclofenac, or photodynamic therapy: within 8 weeks and 2 cm of the selected treatment area.