Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

Yonsei University77 enrolled

Overview

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Coronary Heart Disease

Interventions

AtorvastatinDRUG

Atorvastatin 40mg/D for 6 weeks to improve endothelial dysfunction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * within 1 year * the siblings of premature coronary heart disease(male\<55years old, female\<65years old: Framingham Heart Study)patients admitted relevant hospital Exclusion Criteria: * Documented coronary heart disease * Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.

Locations (1)

Severance Cardiovascular Hospital, Yonsei University College of Medicine

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

improvement of endothelial dysfunction with endo-PAT2000

Time frame: 6 weeks later drug administration

Central Contacts

Hyuk-Jae Chang, MD, PhD

CONTACT

82-2-2228-8461 hjchang@yuhs.ac

Data from ClinicalTrials.gov

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