Investigation Of The Effect Of Steady State Filibuvir On The Pharmacokinetics Of Oral Contraceptives (Levonorgestrel And Ethinyl Estradiol)

Inclusion Criteria: * Healthy female subjects between the ages of 18 and 45 years, inclusive (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ECG and clinical laboratory tests). * Subjects must have been on any combination of ethinyl estradiol and levonorgesterol oral contraceptives for at least one consecutive month prior to Period 1. * Body Mass Index (BMI) of approximately 17.5 to 30.5 kg/m2; and a total body weight \>45 kg. * Evidence of a personally signed and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the trial. * Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other trial procedures. * Must be willing to practice an alternative method of contraception for the duration of the study in addition to oral contraceptive use. Exclusion Criteria: * Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing). * Any medical reason which would contraindicate the administration of oral contraceptives (as per label). Including but not limited to history of unexplained vaginal bleeding, current breast cancer, active liver disease, uncontrolled hypertension, history of diabetes with vascular complications, history of venous thrombosis, stroke, ischemic heart disease, history of severe headaches with focal neurologic symptoms. * Female subjects of non-childbearing potential who meet the following criteria: * Post menopausal, aged between 45-55 who have been amenorrheic for \>2 years and who meet the criteria for serum FSH levels (\>30 IU/L), or * Females who have undergone a hysterectomy, or * Females who have undergone tubal ligation, or * Females who have undergone bilateral oophorectomy. * History of discontinued use of oral contraceptives for medical reasons. * History of febrile illness within 5 days prior to the first dose. * Any condition possibly affecting drug absorption (eg, gastrectomy).