Study to Assess the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of AZD3043

Inclusion Criteria: * Healthy male subjects aged 18 to 45 years with suitable veins for cannulation or repeated venepuncture * Pre-dose assessment judged without remarks by the investigator * Have a Body Mass Index (BMI) between 19 and 30 kg/m2 and weight at least 50kg and no more than 100kg Exclusion Criteria: * After adequate time (at least 15 minutes) of rest in supine position, abnormal vital signs defined as any of the following:· * Systolic blood pressure (BP) \>140 mm Hg.· * Diastolic BP \>90 mm Hg. * Heart rate \<=55 or \>85 beats per minute * Subjects with compromised airway or respiratory function as evidenced by the presence of Class 3 or 4 Airway, Sleep Apnoea, Neck circumference \> 16.5 inches (42 cm), Asthma, Active or recent (2 weeks) respiratory infection, or known chronic respiratory infection, or known chronic respirator * Lack of a normal phenotype for butyrylcholinesterase (pseudo-cholinesterase)