Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis

Inclusion Criteria: * Patients over 18 years old * Provided written consent for participation in the trial prior to any study-specific procedures or requirements * Posterior uveitis or panuveitis associated with macular oedema defined as increased macular thickness (more than 250 mm assessed by Stratus TD-OCT or 300 mm with Cirrus SD-OCT ) and/or the presence of cystoid spaces in the macula, and the absence of epiretinal membranes. * Patient with oral contraception * Posterior uveitis or panuveitis associated with macular oedema * Patients with histologically proven sarcoidosis or a presumed sarcoidosis. In case of a non caseating granuloma in biopsy tissues, the patients with presumed sarcoidosis meet at least 2 of the 4 following criteria: typical changes on chest radiography and computed tomography; predominantly CD4 lymphocytosis in bronchoalveolar lavage (BAL) fluid; elevated serum ACE levels; elevated gallium or 5 fluorodeoxyglucose uptake Exclusion Criteria: * Patients who do not fulfill the inclusion criteria * Other causes of uveitis * Extra ophthalmologic manifestations of sarcoidosis justifying corticosteroids * Patients previously treated with immunosuppressive agents or corticosteroids of more than 10 mg daily over 15 days. * Patients with life-threatening conditions * Chronic hepatopathy or renal failure * Uncontrolled diabetes mellitus