RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer who have undergone surgery and chemotherapy may help doctors predict how well patients will respond to treatment. PURPOSE: This research study is looking at tumor samples from patients with stage III colon cancer who have undergone surgery and chemotherapy.
OBJECTIVES: * Identify predictive factors of efficacy and safety of adjuvant chemotherapy comprising fluorouracil-based regimens in patients with stage III colon cancer. * Investigate possibility of "personalized treatment" with adjuvant chemotherapy based on the predictive factors identified. OUTLINE: Patients' tumor tissue samples are collected for protein expression levels of thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), VEGF, EGFR, mRNA-expression levels of TP, DPD, thymidylate synthase (TS), and orotate phosphoribosyl transferase (OPRT) by ELISA, Human Duo Set, and RT-PCR assays. Patients' enzyme expression levels are compared with their clinical data.
Study Type
OBSERVATIONAL
Enrollment
2,128
Tokyo Medical and Dental University
Tokyo, Japan
Relationship between expression levels of enzymes and disease-free survival, relapse-free survival, and overall survival
Time frame: 5 years after the end of registration
Relationship between expression levels of enzymes and adverse effects
Time frame: 5 years after the end of registration
Disease-free survival
Time frame: Until the day on which an event reveals during the 5 year observational period
Relapse-free survival
Time frame: Until the day on which an event reveals during the 5 year observational period
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