Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy

Inclusion Criteria: * Individuals with clinical evidence of Type 1 Reaction who have not responded to 3 months Prednisolone Treatment * Aged 18-65 * Weigh more than 30Kg Exclusion Criteria: * Unwillingness to give informed consent * Patients with severe active infections such as tuberculosis * Pregnant or breastfeeding women (see Appendix II) * Those with renal failure, abnormal renal function, hypertensive * Patients taking thalidomide currently or within the last 3 months * Patients not willing to return for follow-up * Women of reproductive age not willing to use contraception for the duration of the study ( see Appendix II) * HIV positive