Study of NPC-08 is to Treat for Newly-Diagnosed Malignant Glioma and Recurrent Glioblastoma Multiforme

Inclusion Criteria: * Male or female, aged between 18 and 65 years; * Radiographic evidence on cranial MRI of a single contrast-enhancing unilateral supratentorial cerebral tumor; * Karnofsky Performance Score of 60 or higher; * Willing to practice an effective method of birth control for at least 12 months after wafer implantation surgery; Exclusion Criteria: * More than one focus of tumor or tumor crossing the midline, as assessed by coronal cranial MRI scan; * Prior radiotherapy to the brain; * Prior chemotherapy for the malignant glioma before the baseline evaluation, or patients who were being treated with chemotherapeutic agents; * Known hypersensitivity to nitrosoureas; * Participation in any other investigational protocol in the previous 6 months for any type of malignancy;