Comparison of Neo-adjuvant Weekly Paclitaxel With or Without Carboplatin in Early Breast Cancer

Inclusion Criteria: * female patients between 18 and 65 years old * pathological diagnosed invasive breast cancer; medium and high risk primary breast cancer according to St. Gallen 2007 * able and willing to give consent to participate in the study Exclusion Criteria: * pregnant or lactating females * previous treatment for breast cancer * other tumor history * instable complication (e.g., myocardial infarction within 6 months, arrhythmia, unstable diabetes, hypercalcemia) or uncontrolled infection * allergy history to similar drugs * concurrent disease or condition that would make the patient inappropriate for study participation * resist to participate in the study