Nebulized Colistin for Hospital-Acquired Pneumonia

Phase 3UnknownNCT00920270

Mahidol University140 enrolled

Overview

Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia caused by Gram Negative Bacteria should be more effective than conventional therapy

Randomized Controlled Clinical Trial in hospitalized adult patients with hospital-acquired pneumonia. The patients are allocated to conventional group or nebulized colistin group. The conventional group receives conventional antibiotics whereas the nebulized colistin group receives nebulized colistin in addition to conventional antibiotics. The outcomes are clinical response and microbiological responses.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

140

Conditions

Pneumonia

Interventions

nebulized colistinDRUG

nebulized colistin 75 mg every 12 hours

antibioticsDRUG

conventional parenteral antibiotics

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult (age\>18 years) hospitalized patient with hospital-acquired pneumonia due to Gram negative bacteria Exclusion Criteria: * pregnancy * lactating woman * colistin allergy * severe renal impairment * epilepsy

Locations (1)

Siriraj Hospital

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

Clinical response

Time frame: 14 days after Treatment

Secondary Outcomes

Microbiological response and safety

Time frame: 14 days after treatment

Data from ClinicalTrials.gov

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