COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent

Inclusion Criteria: * Patients with clinical evidence of ischemic heart disease; * No clinical and ECG changes suggestive of ongoing acute infarction; * De novo lesion \> 50% and \<100% diameter stenosis (DS) in native coronary vessels TIMI flow of \>= 1. * Reference diameter \> 2.5 mm or \< 4.0 mm; * Patients with a maximum of two coronary lesions to be treated with a maximum of 2 study stents; Exclusion Criteria: * Lesion length \> 30 mm; * Significant (\>50%) stenosis proximal or distal to the target lesions that might impede run off; * Lesions located in saphenous vein graft; * Lesions located in unprotected left main; * Presence of \> 40% stenosis in the left main; * Ostial lesion; * Lesion located in a bifurcation; * Target lesion with visible thrombus; * Chronic total occlusion; * Treatment of restenotic lesions; * Previous implantation of a stent (BMS/DES) in the target vessel.