Study of NXN 188 for the Treatment of Migraine With Aura

Inclusion Criteria: 1. Male or female migraineurs between 18 and 65 years old. 2. Subjects must have a headache history of migraine with aura as defined by: * Aura consisting of at least one of the following, but no muscle weakness or paralysis: * Fully reversible visual symptoms * Fully reversible sensory symptoms * Fully reversible dysphasia * Aura has at least two of the following characteristics: * Visual symptoms affecting only one side of the field of vision and/or sensory symptoms affecting only one side of the body * At least one aura symptom that develops gradually over more than 5 minutes and/or different aura symptoms occur in succession over more than 5 minutes * Each symptom lasts from 5-60 minutes * Headache begins during the aura or follows aura within 60 minutes * Headache not attributable to another disorder 3. Migraine pain following aura in at least 75% of occurrences 4. Headache frequency of at least 1 migraine attack (with or without aura) per month for the past 3 months but not more than 8 migraines in any 30 day period. Subjects must have at least 1 migraine headache with aura per month • Each migraine attack should last at least 4 hours (without treatment) and not longer than 72 hours. 5. At the time of the study migraine, prior to dosing with study medication, the headache severity, as judged and documented by the subject, is either moderate or severe (on a 4-point categorical scale) 6. Body mass index (BMI) range of 18 to 35 7. The subject is in general good health. • ALT cannot be above 1.5x upper limit of normal; creatinine and urea must be within normal limits 8. Speak, read, and understand English, French, or Spanish sufficiently to understand the nature of the study, to provide written informed consent, and complete all study assessments 9. The subject is willing and able to comply with all testing requirements defined in the protocol 10. All females will avoid pregnancy at least 10 days before randomization, and up until 3 months after dosing. 11. All subjects/partners must use a double-barrier method of birth control during the study and for 3 months after dosing. Exclusion Criteria: 1. A diagnosis of headaches that is not consistent with migraine with aura. 2. Presence of any risk factors that would preclude the use of triptans: 3. Known allergy or hypersensitivity to triptans or history of any serious side effect with a triptan which would preclude further dosing with a triptan 4. Presence of any clinically significant condition that would preclude study participation, as evaluated by the investigator 5. Pregnancy or lactation 6. History of significant neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, rheumatologic, autoimmune, or metabolic disease 7. Use of the following if taken for migraine prevention: * Cardiovascular drugs (acceptable if reason for use is for treatment of cardiovascular disease and the subject has been on a stable dose for 3 months) * Valproate, topiramate, cyproheptadine, montelukast, or botulinum toxin. 8. Use of monoamine oxidase inhibitors within 30 days of randomization 9. Initiation of therapy with SSRIs or SNRIs for depression or other approved indication within 90 days of randomization (subjects on stable dose for \>3 months for treatment of depression or other approved indication may be included) 10. Are known to or suspected to be currently abusing alcohol or drugs, or have a history (within the past 12 months) of active alcohol or drug abuse 11. Participation in another drug or biologic study within 30 days of randomization into this study or during participation in this study 12. Subjects who are unable or unwilling, in the opinion of the Investigator, to comply with all study procedures and cooperate fully with study center staff