Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs

Inclusion Criteria: * Normal healthy adult subjects between 20-40 years of age * Body weight within 80-120% of ideal body weight * Acceptable medical history, physical examination and clinical laboratory determinations Exclusion Criteria: * Recent history of drug or alcohol addiction or abuse * Donating greater than 150 ml of blood within two months prior to Period I * Taking any prescription medication or any nonprescription medication within 14 days prior to Period I doing * Receiving any investigational drug within 30 days prior to Period I dosing * Taking any drug known to induce or inhibit hepatic drug metabolism within 30 days prior to the beginning of the study * Any clinically significant diseases * History of allergic response to nalbuphine or related drugs and traditional Chinese herbs