This study will investigate whether the lacto-tripeptide Ile-Pro-Pro (IPP) improves the function of the endothelium in patients with coronary artery disease. The study has a crossover design. Participants will be treated with a protein hydrolysate rich in IPP for 12 weeks and placebo for 12 weeks with a four-week rest period between treatment periods. The investigators will use ultrasound to test the function of the endothelium in the brachial artery before, after 6 weeks, and after 12 weeks of each treatment. Blood will be collected before and after each treatment. The investigators hypothesize that IPP will improve endothelial function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
54
Protein hydrolysate rich in lacto-tripeptide (IPP) up to 5 to 15 mg/day
Matching placebo capsules
Boston University Medical Center
Boston, Massachusetts, United States
Brachial Artery Flow-Mediated Dilation and Reactive Hyperemia
Time frame: 12 weeks
Carotid-Femoral Pulse Wave Velocity
Time frame: 12 weeks
Leg Reactive Hyperemia
Time frame: 12 weeks
Digital Pulse Amplitude Tonometry
Time frame: 12 weeks
Blood pressure
Time frame: 12 weeks
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