Measuring Response to Depression Treatment

Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc.70 enrolled

Overview

The primary goal of this study is to compare a new symptoms rating questionnaire, called the Vancouver Semi-Structured Interview for Depression (V-SID), to the traditionally used questionnaires. The investigators predict that the V-SID will be more sensitive to patients' improvement than are traditional questionnaires.

Depression is sometimes associated with difficulties in thinking skills. Recent evidence suggests that in those people who have thinking difficulties, effective treatment and improvement of depression can also result in improved thinking skills. Therefore, a test of thinking skills is included in this study. This study will also evaluate three other potential indicators of treatment response: cortisol, cytokines, and grip strength.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Depression

Interventions

Treatment-as-usualOTHER

Eligibility

Sex: ALLMin age: 19 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major depressive episode, diagnosed using the Mini-International Neuropsychiatric Interview (MINI) * Depression not currently effectively treated * Age 19 to 65 years Exclusion Criteria: * Co-morbid Axis I disorders (co-morbid anxiety symptoms, including generalized anxiety or panic attacks, are not exclusionary if they are present in the context of a primary mood disorder)

Locations (1)

Copeman Neuroscience Centre

Vancouver, British Columbia, Canada

Outcomes

Primary Outcomes

Hamilton Rating Scale for Depression (HAM-D)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

Vancouver Semi-Structured Interview for Depression (V-SID)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

Montgomery-Asberg Depression Rating Scale (MADRS)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

Clinical Global Impression

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8, Followup

Hamilton Rating Scale for Anxiety (HAM-A)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

British Columbia Major Depression Inventory (BC-MDI)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

Quality of Life Enjoyment Satisfaction Questionnaire (Q-LES-Q)

Time frame: Day 0, Week 8

Secondary Outcomes

CNS Vital Signs

Time frame: Pre-Baseline, Day 0, Week 8

British Columbia Cognitive Complaints Inventory (BC-CCI)

Time frame: Pre-Baseline, Day 0, Week 1, Week 4, Week 8

Grip strength

Time frame: Pre-Baseline, Day 0, Week 8

Cortisol level

Time frame: Day 0, Week 8

Data from ClinicalTrials.gov

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