Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

University of Zurich120 enrolled

Overview

Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

120

Conditions

Cardiac On-pump Surgery

Interventions

SevofluraneDRUG

Sedation with sevoflurane

PropofolDRUG

Sedation on intensive care unit with propofol

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion criteria: * CABG and/or heart valve surgery with CPB * Ejection fraction (EF) = 30% * Canadian Cardiovascular Society (CCS) classification = 3 * Ages 18 to 90 years old Exclusion criteria: * Pulmonary disease: forced expiratory volume in one second (FEV1) \< 80%; FEV1/forced vital capacity (FVC) \< 70% * Renal disease and/ or creatinine-clearance \< 60 ml/min * Previous cardiac surgery * Emergency procedures * Postoperative intra aortic balloon pump (IABP) requirement * Myocardial infarction \< 7d * Steroid treatment * Insulin-dependent diabetes * Pregnancy

Locations (1)

Unnamed facility

Zurich, Switzerland

Outcomes

Primary Outcomes

Myocardial injury markers (myoglobin, creatine kinase, myocard specific creatine kinase, and troponin T)

Time frame: Start and end of ICU stay

Secondary Outcomes

Oxygenation index, postoperative pulmonary complications, ICU stay (days), length of hospitalisation

Time frame: Start with surgery until end of hospitalisation

Data from ClinicalTrials.gov

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