Familial hypercholesterolemia (FH), an inherited disorder of lipoprotein metabolism, is a risk for early cardiovascular disease (CVD). This autosomal dominant disease is characterized by markedly elevated plasma concentrations of low density lipoprotein (LDL) and total cholesterol (TC). The purpose of this study is to compare the effect of a diet low in saturated fats but enriched either with rapeseed oil (RO) or sunflower oil (SO) in children and adolescents with FH on serum lipoproteins.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
24
rapeseed oil in amounts between 14 and 27 g
sunflower oil
Division of Nutrition and Metabolism, Department of Pediatrics, Medical University of Vienna
Vienna, Vienna, Austria
RECRUITINGBlood analysis including fasting serum lipoproteins (TC, LDLc; HDLc; TG, Lp(a), Apolipoprotein A-1, Apolipoprotein B, BB, hs-CRP, GOT, GPT, GGT, acid composition of plasma lipids.
Time frame: done in Week 1, Week 7, Week 13
Motivation, compliance, increase of quality of life.
Time frame: done in Week 1 and Week 13
Acceptance and approach to the disease.
Time frame: done in Week 1 and Week 13
Improvement of knowledge and understanding about the disease by the patients.
Time frame: done in Week 1 and Week 13
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