Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Aarhus University Hospital

Overview

Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Conditions

Neurosurgery

Interventions

VancomycinDRUG

Vancomycin is administered intravenously and subsequently measured in cerebrospinal fluid sample

TeicoplaninDRUG

Teicoplanin is administered intravenously and subsequently measured in cerebrospinal fluid sample

LinezolidDRUG

Linezolid is administered intravenously and subsequently measured in cerebrospinal fluid sample

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years old * Already having an external CSF drain * Scheduled for neurosurgery requiring antibiotic prophylaxis (most commonly placement of an internal drain ("shunt") Exclusion Criteria: * Infection or colonization requiring other than standard prophylactic antibiotics

Outcomes

Primary Outcomes

Concentration of antibiotics in cerebrospinal fluid

Concentration in CSF past i.v. injection

Time frame: 1, 2, 4, 6, 12 hours

Data from ClinicalTrials.gov

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