We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.
We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH. To study this hypothesis, we have two specific aims: 1. To evaluate plasma MIF concentration as a marker of severity in ILD and PH and 2. To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.
Study Type
OBSERVATIONAL
Enrollment
67
Subject will have both venous and arterial blood draws to assess for the bloods content of MIF
Subject will ride exercise bike to assess their pulmonary function level.
To assess subjects lung function
Interstitial Lung Disease and Pulmonary Hypertension Programs
New Hyde Park, New York, United States
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.