Dexmedetomidine Infusion in Hypospadias Surgery

University of Jordan48 enrolled

Overview

The investigators hypothesize that giving Dexmedetomidine in combination with Fentanyl for pediatric patients undergoing hypospadias surgery, will reduce the fentanyl requirement for intraoperative and postoperative analgesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain

Interventions

Dexmedetomidine and FentanylDRUG

Dexmedetomidine in a dose of 1 ug/kg initial dose then continuous infusion of 0.7 ug/kg/hr . Combined with Fentanyl at a dose of 2 ug/kg initially plus boluses of fentanyl to keep the patient hemodynamically stable.

FentanylDRUG

This group received Fentanyl at a dose of 2 ug/kg initially, followed by boluses to keep the patient hemodynamically stable.

Eligibility

Sex: MALEMin age: 1 YearMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 1-12 years undergoing hypospadias repair Exclusion Criteria: * Allergy to Dexmedetomidine * Preoperative use of sedatives or analgesics * cardiac diseases * Children with mental retardation

Locations (1)

Jordan University Hospital

Amman, Jordan

Outcomes

Primary Outcomes

Intraoperative and postoperative fentanyl requirement (in microg/kg)

Time frame: 6/2008-1/2009

Data from ClinicalTrials.gov

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