AXIS 2: AX200 for the Treatment of Ischemic Stroke

Major Inclusion Criteria: * diagnosis of acute ischemic stroke with an onset within 9 hours prior to start of study agent administration * ischemic stroke in the MCA territory confirmed by MRI (diffusion) * age ≥18 years and ≤85 years * lesion size on DWI ≥15 ccm * written informed consent Major Exclusion Criteria: * prior to current stroke: inability to walk or to lead an independent life * life expectancy less or equal 6 months * stupor or coma * lacunar infarct * any evidence of ICH * malignant hypertension * presence of history of active malignancies * platelet count \<100/nl at randomization * leukocyte count \>20/nl at randomization * congenital neutropenia * pregnant or lactating women