Differential Effects of a Diet Supplementation With Plant Sterol Esters on Human Monocytes

University Hospital, Saarland16 enrolled

Overview

The purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

This study investigates effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hyperlipidemia

Interventions

margarine + plant sterol estersDIETARY_SUPPLEMENT

margarine supplemented with plant sterol esters (3g/day) over the time period of 4 weeks

margarine (placebo)DIETARY_SUPPLEMENT

non-sterol ester supplemented margarine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy individuals without known cardiovascular diseases Exclusion Criteria: * drugs that interfere with cholesterol metabolism * other use of dietary supplements * vegetarianism

Locations (1)

Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III

Homburg, Saarland, Germany

Outcomes

Primary Outcomes

monocyte subpopulations

Time frame: 4 weeks

Secondary Outcomes

serum parameters (lipids, plant sterol concentrations, inflammation parameters)

Time frame: 4 weeks

Data from ClinicalTrials.gov

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