Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant

Inclusion Criteria: * Male or female 18-75 * First kidney transplant from a living or deceased donor * Receiving CNI and MPA * Able to tolerate full dose MPA * Calculated glomerular filtration rate \>=30ml/min by Cockcroft-Gault equation * Able to tolerate renal graft biopsies * Provided written, informed consent * Females of childbearing potential must have a negative pregnancy test within 48 hours prior to the first Simulect administration Exclusion Criteria: * Known hypersensitivity to Simulect * Current preformed PRA\>10% * Multi organ or second kidney transplant * Use of any investigational immunosuppressive drug within 1 month of inclusion * Female patients who are pregnant, lactating or of child bearing potential and not practicing two approved methods of birth control * Known malignancy or history of malignancy other than excised basal or squamous cell carcinoma of the skin * HBV, HCV, or HIV positive patients * Current severe infection * Receiving an organ from an extended criteria donor per United Network for Organ Sharing (UNOS) guidelines * Dialysis dependent one month post transplant * Live too far away from the transplant center for adequate follow up