Peripheral Effects of Endotoxin on Insulin Resistance

Aarhus University Hospital8 enrolled

Overview

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

USP endotoxinBIOLOGICAL

Continuous intra-arterial infusion

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Normal health 2. 22 \< BMI \< 28 3. Written Informed Concent Exclusion Criteria: 1. Any disease 2. Any use of medication 3. Recent immobilization of a lower extremity

Locations (1)

The Medical Research Laboratories, Dept. M, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

glucose concentration

Time frame: 360 minutes observation

Secondary Outcomes

Regional arteriovenous amino-acid balance

Time frame: measured at t=180 and 360 minutes

Intra-cellular insulin signaling

Time frame: measured at t=0, 120, and, 210 minutes

Regional arteriovenous lipid balance

Time frame: measured at t=180 and 360 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.