This is a randomized, double-blind, placebo-controlled study to evaluate the effects of lebrikizumab in patients with asthma who remain inadequately controlled while on chronic therapy with inhaled corticosteroids (ICS).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
218
Subcutaneous repeating dose
Subcutaneous repeating dose
Change in forced expiratory volume in 1 second (FEV1)
Time frame: From baseline to Week 12
Change in pre-bronchodilator FEV1
Time frame: From baseline to Week 24
Change in quality of life and symptom scores
Time frame: From baseline to Week 12
Change in peak flow
Time frame: From baseline to Week 1
Rate of asthma exacerbations
Time frame: During the 24 week treatment period
Change in rescue medication use
Time frame: From baseline to Week 1
Frequency and severity of adverse events
Time frame: Through study completion or early study discontinuation
Incidence of human anti-therapeutic antibodies (ATA)
Time frame: At the end of the follow-up period
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