Study of [3H] BMS747158 in Healthy Male Subjects

Inclusion Criteria: 1. Provide written signed informed consent prior to any study procedures 2. Be healthy as determined by no clinically significant deviation from normal in medical history, physical examination, vital signs, ECG, and clinical laboratory tests 3. Have a Body Mass Index (BMI) of 18 to 30 kg/m2 4. Be male, age 18 to 45 years 5. Be sterile or agree to use from admission until discharge one of the following approved methods of contraception: * a male condom with spermicide * a sterile sexual partner * use by female sexual partner of an intrauterine device (IUD) with spermicide \*a female condom with spermicide contraceptive sponge with spermicide * an intravaginal system \[e.g., NuvaRing®\] * a diaphragm with spermicide * a cervical cap with spermicide, or * oral, implantable, transdermal, or injectable contraceptives 6. Must be able to communicate effectively with study personnel Exclusion Criteria: 1. Any significant active or chronic medical illness or acute significant trauma 2. History of any condition that may disrupt and/or increase permeability of the blood-brain barrier or diabetes 3. History of any neurological disease. 4. History of concussion or meningitis within the past 6 months 5. History of sleep disorders, including snoring with sleep apnea and narcolepsy 6. History of anxiety disorder 7. Current or recent GI disease 8. Major surgery within 4 weeks 9. GI surgery that could impact upon the re-absorption of study drug 10. History of chronic constipation 11. History of asthma as deemed clinically significant by the Investigator or designee 12. History of recent (within 2 weeks of enrollment) infection (e.g., upper respiratory tract infection, urinary tract infection) 13. Known and confirmed drug allergies or hypersensitivities 14. Donation of blood and/or plasma to a blood bank or in a clinical study (except as required for screening) within four weeks of enrollment 15. Blood transfusion within four weeks of enrollment 16. Inability to tolerate intravenous medication or unlikely to obtain and/or tolerate venous access 17. Past (6 months) or present history of drug or alcohol abuse 18. Screening or pre-dose ECG interval abnormalities or organ dysfunction. 19. Positive urine screen for drugs of abuse either at screening or before dosing 20. Positive blood screen for hepatitis B surface antigen, hepatitis C antibody, or HIV 21. Exposure to any investigational drug, device, or placebo within four weeks of enrollment 22. Use of any prescription drugs within 4 weeks of enrollment 23. Use of any other drugs, including over-the-counter medications (e.g., acid-controllers) and herbal preparations within two weeks of enrollment 24. Smoking within 1 month of enrollment 25. Alcohol or caffeine consumption within 72 hours of study drug administration 26. Participation in a radio-labeled study within 12 months of enrollment 27. Intake of radio-labeled drug substance or exposure to significant radiation 28. Participation in any prior study with BMS747158