Evaluation of the Influence of Statins and Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects

Inclusion Criteria: * Subject must be 18 years of age or older * Bare metal stent implantation * Discharged with dual antiplatelet therapy for at least 60 days * Written informed consent Exclusion Criteria: * Patients who do not consent to participate in the study * Premenopausal women not using contraceptive methods or without a negative pregnancy test in the past week * Patients treated or planned to be treated with oral anticoagulants * Present treatment with or clear indication for treatment with a PPI or H2 antagonists * Allergy or intolerance to study medications including ranitidine, Proton pump inhibitors, atorvastatin, rosuvastatin, aspirin and/or clopidogrel * Patient treated with a strong CYP2C19 interacting drug * History of a bleeding diathesis, or evidence of active abnormal bleeding within 30 days before enrollment * History of intracranial hemorrhage or intracranial surgery in the last 3 months * History of gastro-intestinal ulcers in the last 3 months * Any serious illness or any condition that the investigator feels would influence the impact of this therapy on the subject * Known platelet count \< 100000/mm3 at time of enrollment or within 24 hours prior to enrollment