Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement10 enrolled

Overview

Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Overweight

Interventions

Postprandial metabolic and functional measuresDIETARY_SUPPLEMENT

After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 25 and 30 * Waist circumference \> 94 cm Exclusion Criteria: * Allergy to milk protein * Abusive drug consumption * Smoking * Hypertension, diabetes * High level of physical activity

Locations (1)

Centre de recherche sur volontaires

Bobigny, France

Outcomes

Primary Outcomes

Endothelial dysfunction

Time frame: 0-2-4-6 hours (after meal ingestion)

Secondary Outcomes

Postprandial inflammation

Time frame: 0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.