Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia

Lund University195 enrolled

Overview

The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV testing, as compared to cytology, to predict recurrence of high-grade CIN.

Cervical samples for human papillomavirus (HPV) DNA analysis and cytological analysis were obtained from women with abnormal smears referred to Umeå university hospital, Sweden, for treatment with conization. These women were scheduled for HPV DNA testing and Pap smears before and 3, 6, 12, 24 and 36 months after treatment. The HPV DNA testing was performed with a PCR-based genotyping method.

Study Type

OBSERVATIONAL

Enrollment

195

Conditions

Human Papillomavirus Infection Cervical Intraepithelial Neoplasia

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Referral to Umeå university hospital for treatment due to abnormal Pap smear. Exclusion Criteria: * Lack of informed consent.

Locations (1)

Dept. obstetrics and gynecology, University hospital of Northern Sweden

Umeå, Sweden

Data from ClinicalTrials.gov

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