Developing Biomarkers for Fibromyalgia

Inclusion Criteria: Inclusion Criteria for Fibromyalgia Volunteers: * Has met American College of Rheumatology (1990) criteria for the diagnosis of fibromyalgia for at least 1 year * Chronic pain more than 50% of days * Willing to limit introduction of any new medications or treatments for fibromyalgia during the study * Able to attend study visits up to three times weekly * Right-handed * Be capable of giving written informed consent Inclusion Criteria for Healthy Volunteers: * Willing to refrain from alcohol intake for 48 hours prior to brain scans * Be right handed * Be capable of giving written informed consent PET Inclusion Criteria: * Willing to refrain from alcohol intake 48 hours prior to brain scans * Capable of giving written consent Exclusion Criteria: Exclusion Criteria for Fibromyalgia Volunteers: * Knowledge that could prevent "blinding" of the participant to the study interventions (including previous acupuncture treatment) * Presence of a known coagulation abnormality, thrombocytopenia, or bleeding diathesis that may preclude the safe use of acupuncture * Autoimmune or inflammatory disease (in addition to fibromyalgia) that causes pain (e.g., rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease) * Daily use of narcotic pain-relievers * History of substance abuse * Simultaneous participation in other therapeutic trials * Pregnant or breastfeeding * Current severe psychiatric illness (e.g., schizophrenia, major depression with suicidal ideation) * Condition that may make exposure to fMRI medically inadvisable * Any condition that may prevent satisfactory completion of the study protocol Exclusion for Healthy Volunteers: * Autoimmune or inflammatory disease (in addition to fibromyalgia) that causes pain (e.g., rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease) * Having met the ACR criteria for FM * Simultaneous participation in other therapeutic trials * Pregnant or breastfeeding * Current severe psychiatric illness (e.g., schizophrenia, major depression with suicidal ideation) * Condition that may make exposure to fMRI medically inadvisable * Any condition that may prevent satisfactory completion of the study protocol PET Exclusion Criteria: * Meets any of the fMRI exclusion criteria * Current major depression * Condition that may make exposure to PET medically inadvisable