Characterization of Low Density Lipoprotein and Mechanism of the Pro Aggregant Effect Through Oxidant Stress and Lipid Exchange

N/ACompletedNCT00932087

Hospices Civils de Lyon48 enrolled

Overview

Case control design: lipidomic study in 12 type 2 diabetics with metabolic syndrome, 12 metabolic syndrome without diabetes, 12 subjects with type 1 diabetes and 12 controls

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes Metabolic Syndrome

Interventions

Blood samplePROCEDURE

Blood sample for lipidomic study

Eligibility

Sex: MALEMin age: 30 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * statin and fibrate Wash out for one week * HbA1c\>7% and \<12% (Arms 1 and 3) * HbA1c\<6% (Arms 2 and 4) * Metabolic sd according NCEP III (3 out 4 criteria) (Arms 1 and 2) Exclusion Criteria: * secondary CV prevention

Locations (1)

Fédération d'Endocrinologie-Diabétologie-Maladies métaboliques-Nutrition - Hôpital Cardiovasculaire et Pneumologique

Lyon, France

Outcomes

Primary Outcomes

Level of plasma isoprostane and lipoperoxides

Time frame: at baseline

Secondary Outcomes

TXA2 and PF4 levels after platelet activation of control platelet exposed to LDL

Time frame: 2 hours

Data from ClinicalTrials.gov

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