Comparison of Standard Versus Low Dose Advagraf® With or Without Angiotensin-converting Enzyme Inhibitor (ACEi)/Angiotensin Receptor Blocker (ARB) on Histology and Function of Renal Allografts

Inclusion Criteria: * Subject is the recipient of a first or second deceased or living donor renal transplant (one kidney only) * Subject must have at least one HLA-mismatch with the donor. HLA identical donor-recipient pairs are not eligible * Subject understands either English or French * If female and of child-bearing potential, subject has a negative pregnancy test and utilizes adequate contraceptive methods Exclusion Criteria: * Presence of donor specific antibody * Subject who is currently participating in a study with investigational drug, or who has received investigational drug within three months prior to randomization. Observational studies are acceptable * Subject who has lost a previous graft for immunological reasons less than one year from transplant * Subject is pregnant or breastfeeding * Subject receives a kidney lacking pre-implantation biopsy * Subject has significant disease (e.g. malignancy or uncontrolled infection) or disability (e.g. cognitive defect) which prevents understanding of, or adherence to the protocol * Subject who in the opinion of the Investigator, require ACEi/ARB therapy post-transplant for any indication * Subject who requires induction with Thymoglobulin, Campath, antithymocyte globulin (ATG), antilymphocyte globulin (ALG) or any biological induction agent other than basiliximab. Unplanned post-transplant use of these prohibited drugs for clinical indications post-transplant is allowed * Subject has plans to become pregnant within 2 years post-transplant * Subject who has a positive T-cell or B-cell crossmatch. Subjects with a weakly positive B-cell cross-match that tests negative following DTT reduction are acceptable * Subject who has a requirement for maintenance immunosuppressant therapy with the exception of low dose steroid or mycophenolate mofetil (MMF). A subject who is on low dose tacrolimus maintenance therapy will be eligible provided the tacrolimus is withheld at least 1 week prior to transplant