Study of a Topical Formulation for the Treatment and Prevention of Raynaud's Phenomenon Symptoms

Inclusion Criteria: * clinical diagnosis of Raynaud's phenomenon as determined by a history of cold sensitivity with pain, numbness, and/or tingling along with pallor or cyanosis of the fingers * a history of at least two Raynaud's events during a typical winter day * must be willing to apply creams to fingers * must be willing to undergo cold temperature exposure * must be willing and able to stop certain medications * must be willing to use effective contraception, if applicable Exclusion Criteria: * had a Raynaud's attack that required hospital or clinic intervention * has allergies to nitroglycerin or topical medication ingredients * has a history of migraine or chronic pain * has an unstable medical problem that could interfere with the study * had a heart attack or uncontrolled heart problems, hypertension, or hypotension in the past 3 months * used any investigational drug in the past 4 weeks * has significantly abnormal laboratory tests * had certain major surgeries in the past 6 months * has skin lesions on certain parts of the fingers * women who are pregnant or nursing