The purpose of this study is to investigate the ability of propranolol to decrease pain and improve recovery in burn patients with a common genotype.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
45
Washington Hospital Center
Washington D.C., District of Columbia, United States
North Carolina Jaycee Burn Center
Chapel Hill, North Carolina, United States
Wake Forest University Baptist
Wake Forest, North Carolina, United States
Crozer Chester Medical Center
Upland, Pennsylvania, United States
Overall Pain Trajectory Slopes
Overall pain trajectory slopes by treatment group, where linear mixed modeling was used to combine pain measurements (waking, worst, and least pain) assessed on primary outcome days into an overall pain score. Pain was assessed using a 0-10 numeric rating scale (NRS). A lower score on the NRS indicated less pain and a higher score was indicative of worse pain.
Time frame: Study days 5, 7, 10, 13, 17 and 19
Sleep Quality
Medical Outcomes Survey Sleep Quality Subscale. This is a 0-10 numeric rating scale in which patients rate their sleep quality. 0 represents poor sleep quality whereas 10 represents a restful night of sleep.
Time frame: 6 weeks after injury timepoint was chosen for this analysis
Itch Symptoms
Average itch intensity measured with a 0-10 numeric rating scale, 6 weeks was used as main outcome timepoint for itch symptom burden. 0 represents no itch symptoms and 10 represents the most severe itch symptoms.
Time frame: Week 6 after injury was chosen as the main timepoint of interest
Anxiety Symptoms
Anxiety severity via the State Trait Personality Inventory (STPI), range 10-40, 40 represents high anxiety.
Time frame: 6 weeks after injury was chosen as the main timepoint of interest
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