Matrix Metalloproteinase-1/Tissue Inhibitor of Metalloproteinase-1 (MMP-1/TIMP-1) Ratio and Diabetic Foot Ulcers

Inclusion Criteria: * Patients with type 1 or type 2 diabetes * Age over 40 * Chronic diabetic foot ulcer (duration over 30 days) * Grade 1 to 3, stage A and C according to the University of Texas Wound Classification, except stage B and D * Wound area over 0.5 cm² * Social Security membership or benefit from Social Security * Informed consent, with a signed and approved form * Possibility to have clinical follow-up and compliance during 3 months Exclusion Criteria: * Urgent need for locoregional surgery * Clinical criteria for infection, defined by the presence of pus or/and at least 2 local signs among the following: heat, erythema, lymphangitis, lymphadenopathy, oedema, pain * Other pathology that could interfere with the healing process (vasculitis, connectivitis, dysimmunity, immunosuppressive treatment or corticoids, ongoing radiotherapy or chemotherapy ) * Any severe pathology that would constitute a contra-indication to the patient's inclusion * Ongoing therapeutic research protocol * Underage patient, major patient under guardianship or protected by the Law * Pregnant, parturient or breastfeeding woman * Person with no freedom (prisoner), person in an emergency situation, person hospitalized without consent and not protected by the Law