Pharmacokinetics and Pharmacodynamics Study of Saxagliptin in Healthy Subjects

Inclusion Criteria: * Men and women ages 18 to 45 inclusive * Healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations * Body Mass Index (BMI) of 18 to 32 kg/m², inclusive. BMI = weight (kg)/ \[height (m)\]² Exclusion Criteria: * WOCBP who are unwilling or unable to use acceptable barrier methods (condoms and spermicides) to avoid pregnancy for the entire study period and for up to 8 weeks after the last dose of investigational product * Any significant acute or chronic medical illness * Current or recent (within 3 months) gastrointestinal disease * Any major surgery within 4 weeks of study drug administration * History of allergy to DPP4 inhibitor or related compounds * Prior exposure to saxagliptin