Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects

Inclusion Criteria: Subjects enrolled will be nondemented, male and female individuals who meet the following inclusion criteria: * 75 years of age or older * Fluent in English * Stable medical condition for at least 4 weeks prior to Screening visit * Stable dose of non-excluded medications for at least 4 weeks prior to Screening visit Exclusion Criteria: * Dementia * Mild Cognitive Impairment (Amnestic MCI) * Clinically significant neurologic disease * Clinically significant or unstable medical conditions that would interfere with participation in the trial * Known hypersensitivity to guanfacine * History of alcohol or substance abuse or dependence within the past 5 years * Active major psychiatric disorders, including major depression * History of mental retardation * Significant abnormalities on clinical laboratories, ECG, or physical examination * Impairment of visual or auditory acuity sufficient to interfere with completion of study procedures * Education level \< 6 years