Aging is typically associated with a decrease in skeletal muscle mass and muscle function, which contributes decisively to disability in old age and to the loss of quality of life.Resistance exercise can increase muscle strength, function and mass in older adults. The primary aim of this study is to determine whether the combination of resistance training with a supplementation of a cysteine- rich whey protein isolate (Immunocal) compared to combination of resistance training with casein used as control (casein contains little cysteine) could have the potential to provide a synergic beneficial impact on muscle mass and function which could translate to an improved quality of life in elderly persons.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE
Enrollment
99
20 grams per day of Immunocal for 135 days.
20 grams per day for 135 days
Institut de recherches cliniques de Montréal
Montreal, Quebec, Canada
The mean of percent change in muscle strength based on leg press and chest press evaluation assessed by resistance training equipment
Time frame: 45, 90, 135 days
The mean of percent change in muscle strength based on hand-grip dynamometer
Time frame: 45, 90 and 135 days
Percent change in lean body mass evaluated by DEXA.
Time frame: 40, 90 and 135 days
The change in the plasma concentrations of Tumor Necrosis Factor-alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), glutathione, cysteine, asparagine, leucine and albumin
Time frame: 40, 90 and 135 days
The clinical assessment of subject performance status (Quality of life and cognition, Physical Performance Test (PPT)).
Time frame: 40, 90 and 135 days
Insulin sensitivity evaluated by fasting plasma glucose and insulin (HOMA-IR model).
Time frame: 40, 90 and 135 days
The % change in body weight.
Time frame: 40, 90 and 135 days
Bone mass density
Time frame: 40, 90 and 135 days
6-min walk test
Time frame: 40, 90 and 135 days
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