Effects of Unloading on Muscle Mass

Maastricht University Medical Center15 enrolled

Overview

In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Immobilization Physical Inactivity

Interventions

unloadingBEHAVIORAL

2 weeks of unloading of a single leg

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * BMI \< 30 kg/m2 Exclusion Criteria: * Use of medication that may affect haemostasis * Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches * Subjects with metal implants in their lower limbs * Subjects with known cardiovascular and/or haemostasis disorders * Subjects with known severe hypertension

Locations (1)

Maastricht University Medical Centre

Maastricht, Netherlands

Outcomes

Primary Outcomes

muscle mass, muscle fiber size

Time frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Secondary Outcomes

muscle strength

Time frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Data from ClinicalTrials.gov

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