Assessment of Renal Physiology by Magnetic Resonance Imaging (MRI) in Normal Volunteers

University Health Network, Toronto24 enrolled

Overview

Estimation of Glomerular Filtration Rate (GFR) is the primary test used to assess patients with renal disease. Although serum creatinine based GFR and nuclear medicine based estimations are routinely used in clinical practice, GFR estimation by Inulin is the recommended gold standard. Inulin based estimation of GFR is cumbersome and time consuming. A decrease in blood flow to the kidney (Renal Blood Flow (RBF)) is known to cause a decrease in GFR. RBF is typically determined using radioactive tracers, contrast MRI or a cumbersome para-aminohippuric acid (PAH) clearance method. MRI based assessment of GFR and RBF have been suggested to provide reasonable accuracy. Most of these studies did not compare the GFR and RBF estimation directly to Inulin and PAH clearance which are ther gold standards . In this study we propose to estimate MRI based GFR estimation directly to Inulin and noncontrast MRI based derived RBF to PAH to assess if MRI is an accurate test of kidney function.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Glomerular Filtration Rate Renal Blood Flow

Interventions

Inulin and PAH clearance and MRIPROCEDURE

GFR and renal blood flow estimation by Inulin and PAH clearance will be performed in the Renal Physiology Lab for approximately 2.5 hours; The MRI test will be performed afterwards at Medical Imaging department and last about 45 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy male or female volunteers with no known renal disease * Ages between 18-65 years * Normal routine urinalysis * Estimated GFR (eGFR) \>=90mls/min * Arterial pressure \< 130/85 * No medications (birth control pills and vitamins are acceptable) Exclusion Criteria: * Pregnancy * Age \<18y or \>65y * Proteinuria or hematuria as determined by routine urinalysis * Estimate GFR (eGFR) \< 90 ml/min * Known history or requirement of treatment for hypertension * Known allergy to inulin or PAH * MRI contrast allergy, general contraindications to MRI such as pacemaker, etc.

Locations (1)

University Health Network

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

GFR estimation comparison between results obtained by MRI and Inulin clearance method. Blood flow estimation comparison between results obtained by MRI and PAH clearance method.

Time frame: 1 year

Data from ClinicalTrials.gov

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