SAR 1118 in Human Subjects Undergoing Pars Plana Vitrectomy

Inclusion Criteria: * Human subjects meeting the following criteria will be enrolled: * Age ≥18 years * BCVA ≤20/40 in the study eye (BCVA measured at 4M ETDRS) * Male or female * Current non-smoker (last date of smoking should be at least 60 days before study enrollment) * Surgically eligible to undergo elective PPV including, but not limited to, epiretinal membrane, vitreomacular traction, macular holes, or retinal detachment. The elective surgery must be able to be scheduled at least 21 days in advance to allow time for screening and for initiation of study drugs. * Females must be non-pregnant, non-lactating, surgically sterile for at least 3 months, post-menopausal for at least 1 years with follicle stimulating hormone (FSH) greater than or equal to 40 mIU/mL, or willing to use an approved method of contraception from 35 days prior to first study drug administration. Approved methods of contraception include: a non-hormonal intrauterine device (IUD) with spermicide, a female condom with spermicide, a diaphragm with spermicide, a cervical cap with spermicide, use of a condom with spermicide by sexual partner or sterile sexual partner. * Willing and able to provide written informed consent after the nature of the study has been explained, and prior to any research-related procedures. * Willing and able to comply with all study procedures including follow-up instructions Exclusion Criteria: * Individuals not eligible to participate in this study include those who meet any of the following criteria: * Vitreous hemorrhage * Active retinal detachment * Autoimmune disease of the anterior segment or posterior chamber including chronic keratoconjunctivitis sicca, uveitis, iritis/scleritis, blepharitis of either eye * Glaucoma requiring topical medications, infectious conjunctivitis, keratitis, or endophthalmitis of either eye * Prior vitrectomy or intraocular lens placement, within 90 days of Day 0 * Previous intravitreal drug delivery administered in the study eye within the following time period of Day 0: * Intravitreal steroid given ≤3 months * Intravitreal vascular endothelial growth factor inhibitors given ≤2 months * Previous participation in any studies of investigational drugs within 1 month preceding Day 0 * Any concurrent ophthalmic over-the-counter or topical ocular pharmaceutical within 30 days of Day 0 with the exception of saline tear lubricant. * History of malignancy, renal insufficiency, or hepatic insufficiency * Positive serum pregnancy test * Use of any oral, implantable, or injectable contraceptive within 30 days or 5 half-lives of the contraceptive (whichever is longer) prior to first study drug administration; patients must refrain from these types of contraceptives during the treatment period and may resume the use of such contraceptives following the 1-week observation period. * Any history of excessive alcohol (as judged by the Investigator) or illicit drug use/abuse * Consumption of any alcohol or any illicit drugs within one week of first study drug administration * Use of any tobacco or nicotine-containing products within 2 months prior to first study drug administration * Any laboratory abnormality considered clinically significant by the Investigators * Subjects with a hemoglobin \< 12.0 g/dL * Any clinically significant acute or chronic medical condition that would preclude participation in a clinical study * Any history of autoimmune disease, immunodeficiency disorder, positive HIV, acute hepatitis A (IgM positive), or hepatitis B, or C, or organ or bone marrow transplant * Participation in an ongoing investigational drug or medical device study