The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
15
Viagra treatment to patients with sickle cell anemia.
Baruch Padeh Poria Medical Center
Tiberias, Lower Galilee, Israel
endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension
Time frame: January 2009 till January 2011
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