A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care

Inclusion Criteria: * Meets DSM-IV criteria for single or recurrent nonpsychotic MDD, and whom the physician deems it necessary to start on an antidepressant. * Meets clinical criteria for type 2 diabetes as follows: (1) on pharmacological treatment for type 2 diabetes and/or (2) fasting plasma glucose \> 126mg/dL on 2 separate occasions or an abnormal oral glucose tolerance test (OGTT) (2-hours post load glucose ≥ 200mg/dL). * HbA1C \> 7 * Ability and willingness to provide written informed consent * Hamilton Rating Scale for Depression (HRSD) score ≥ 14 * Not on antidepressant medication for at least 2 weeks prior to screen (or 6 weeks in the case of fluoxetine or monoamine oxidase inhibitors - MAOIs) Exclusion Criteria: * Women who are pregnant or breastfeeding * Type 1 diabetes * General medical conditions that contraindicate use of antidepressant medications * Unstable medical illnesses, such as uncontrolled hypertension or symptomatic cardiovascular disease, such as congestive heart failure or angina * Current or past psychotic disorders including bipolar disorder (I, II, or NOS), schizophrenia, or schizoaffective disorder; anorexia; bulimia * High risk for being unable to complete the study due to hospitalization, suicide attempts, significant self-mutilation, or other self-injurious or destructive behavior * Concomitant pharmacological or psychotherapeutic treatment including but not limited to anxiolytics, neuroleptics, mood stabilizers, and/or other agents without proven antidepressant efficacy; cognitive behavioral therapy; current use of other medications that would be contraindicated with antidepressant treatment, as determined by the study doctor * History of current substance or alcohol dependence requiring detoxification within the last 6 months * Currently suicidal or considered a high suicide risk * Require inpatient treatment for their depression