Mare's milk consumption could improve the well-being in patients with Crohn's disease and ulcerative colitis, respectively.
Background: Dietetic effects of mare's milk have been reported for a long time and can be based on bactericidal and immunological components of mare's milk. Objective: Dietetic effects of oral intake of mare's milk in adolescent patients with chronic inflammatory bowel diseases were investigated. Design: In a randomized, placebo-controlled, double-blind, cross-over intervention study, eight Crohn's disease patients and nine ulcerative colitis patients received daily 250 mL mare's milk or placebo drink.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
17
oral intake of 250 ml mare's milk first, then placebo drink daily during 8 weeks of each (cross over design)
oral intake of 250 ml placebo drink first, then mare's milk daily during 8 weeks of each (cross over design)
Friedrich Schiller University Jena, Department of Nutritional Physiology
Jena, Thuringia, Germany
University of Jena, Institute of Nutrition, Department of Nutritional Physiology
Jena, Thuringia, Germany
Score of Crohn´s Disease and/or Ulcerative Colitis
score for Crohn´s disease: Crohn´s Disease Activity Index (CDAI), \< 150 = remission, 151-220 = moderate activity, 221-450 = severe activity; score for ulcerative colitis: Colitis Activity Index (CAI), 0-4 = remission, 5-9 = low activity, 10-16 = moderate activity, 17-23 = high activity.
Time frame: 8 weeks
Extra-intestinal Pain
The patients recorded daily their extraintestinal disorders (fever, anal fissures, stomatitis, arthralgia, skin irritation) using a treatment improvement protocol (TIP).
Time frame: 8 weeks
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