The Effect of Aerobic Exercise on Mild Traumatic Brain Injury

US Department of Veterans Affairs24 enrolled

Overview

The current project will examine the effects of aerobic exercise on cognition among a group of veterans who have suffered a mild traumatic brain injury.

There is substantial evidence that a large number of individuals who experience TBI will demonstrate life-long deficits in cognitive or social functions. An estimated 80-90,000 Americans with TBI suffer life-long impairment of physical, cognitive, and psychosocial skills to the degree that they are unable to return to school or work. Research on rehabilitation for mTBI has been minimal and typically has focused on speech, pain management, dizziness, fatigue, irritability, and sensory disorders. The results of the few studies that have examined long-term cognitive effects of mTBI have offered conflicting results. The current research will investigate the efficacy of an aerobic exercise intervention among individuals with mild traumatic brain injury (mTBI). This project will examine changes in fractional anisotropy (FA) values and cognitive functioning among individuals diagnosed with mTBI in a monitored aerobic exercise regimen, versus a low impact stretching and toning control group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Traumatic Brain Injury

Interventions

aerobic exerciseOTHER

, participants assigned to the exercise treatment group of the proposed study will participate in an aerobic exercise regimen of brisk walking on a treadmill for a 60 minute interval, three times a week

stretching/toningOTHER

Individuals in the control group will participate in a low intensity stretching and toning session for 60 minutes, three times a week

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Anyone between 18 and 50 years of age, * from the geographic region served by the Malcolm Randall-North Florida-South Georgia VAMC, * who have sustained a TBI and demonstrate impairment on neuropsychological assessment (criteria for mTBI will be defined as a loss of consciousness for not more than 30 minutes and post-trauma amnesia of not more than 24 hours). Exclusion Criteria: * TBI occurring less than 6 months or greater than 5 years prior to enrollment, * any metal implants or shrapnel that may put them at risk for injury during an MRI scan, * significant cognitive impairment (MMSE\<24), * history of stroke, * B-12 deficiency, * hypothyroidism, * organ failure (renal, hepatic, cardiac, or lung), * substance abuse, * seizures, * or any limitation that would preclude them from safely engaging in the aerobic exercise regimen.

Locations (1)

North Florida/South Georgia Veterans Health System

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Diffusion Tensor Imaging

Time frame: 16 weeks

Secondary Outcomes

Trail Making Test - Part A

Time frame: 16 weeks

Symbol Search

Time frame: 16 weeks

California Verbal Learning Test - Second Edition (CVLT-II).

Time frame: 16 weeks

Brief Visual Memory Test - Revised (BVMT-R).

Time frame: 16 weeks

Adaptive Digit Ordering Test (DOT-A).

Time frame: 16 weeks

Continuous Performance Test of Attention (CPT-A).

Time frame: 16 weeks

Delis-Kaplin Executive Function System Tower Test

Time frame: 16 weeks

Trail Making Test - Part B.

Time frame: 16 weeks

Controlled Oral Word Association Test (COWAT).

Time frame: 16 weeks

Boston Naming Test (BNT).

Time frame: 16 weeks

Judgment-Line Orientation (JLO).

Time frame: 16 weeks

Grooved Pegboard Test

Data from ClinicalTrials.gov

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