Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis

Inclusion Criteria: * 18-80 years old and capable of giving informed consent. * at least a 6-month history of chronic moderate to severe psoriasis and a candidate for systemic therapy. * BSA covered with psoriasis of at least 5 % or more at Baseline. * An history of coronary atherosclerosis or at least three risk factors among the following: hypertension, active smoking, diabetes mellitus, dyslipidemia, obesity, microalbuminuria, age above 55 years, and first degree relative with coronary atherosclerosis before 65 years. * Patient must be on a stable dose for at least 8 weeks before baseline if taking medications used to control angina, hypertension, serum lipids and any medication that can have an effect on inflammation. * Patient has a carotid or ascending aorta atherosclerotic plaque inflammation target-to background ratio of 1.6 or more as determined by 18-FDG uptake measured by PET scanning. * Female patient is either not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile, or is of childbearing potential and practicing one of the following methods of birth control throughout the study and for 150 days after study completion: * condoms, sponge, foams, jellies, diaphragm or IUD. * contraceptives for three months prior to study drug administration * a vasectomized partner. * Female patient of childbearing potential must have a negative serum pregnancy test at the Screening visit. * Patient is judged to be in good general health as determined by the principal investigator. * Patient will be evaluated for latent TB infection with a PPD or a Quantiferon Gold test and CXR. Patient who demonstrates evidence of latent TB infection will only be allowed to participate in the study if they are willing to use TB prophylaxis according to Canadian guidelines * Patient must be able and willing to provide written informed consent and comply with the requirements of this study protocol. * Patient must be able and willing to self-administer SC injections or have a qualified person available to administer SC injections. Exclusion Criteria: * Patient has other active skin diseases or skin infections (that may interfere with evaluation of psoriasis or with patient's safety. * Patient has a history of an allergic reaction or significant sensitivity to constituents of study drug, including latex. * Patient used any non-biological systemic therapy for the treatment of psoriasis less than 30 days before Day 0. Investigational chemical agents must be discontinued at least 30 days or five half-lives prior to the Baseline visit (whichever is longer). * Patient who has used any biological therapy for the treatment of psoriasis less than 3 months (90 days) before Day 0. * Patient is taking or requires oral or injectable corticosteroids during the study. Inhaled corticosteroids for stable medical conditions are allowed. * Patient has used any topical treatment for psoriasis or has used phototherapy within the last 2 weeks prior to baseline (at the exception of low strength (hydrocortisone and desonide) topical corticosteroid for the face, groin (including genitals) and inframammary areas). * Patient has received Anakinra/Kineret within the last 2 weeks prior to the Baseline visit or is likely to receive Anakinra/Kineret during the course of the study. * Patient has a poorly controlled medical condition, such as uncontrolled diabetes, documented history of recurrent infections, unstable ischemic heart disease, congestive heart failure a left ventricular ejection fraction of less than 40%, recent stroke, chronic leg ulcer or any other condition which, in the opinion of the investigator, would put the patient at risk if participating in the study. * Patient had a myocardial infarction or hospitalization for a cardiac condition within the past 12 weeks. * Patient has a history of acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft, or carotid revascularization within 12 weeks of baseline. * Patient for whom a change in medical treatment for angina, serum lipids, hypertension or any other medication that can have a significant effect on inflammation is planned for the duration of the study. * Patient has a history of neurologic symptoms suggestive of central nervous system demyelinating disease. * Patient has history of cancer or lymphoproliferative disease other than a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma and/or localized carcinoma in situ of the cervix. * Patient has a history of listeriosis, treated or untreated TB, persistent chronic infections, or recent active infections requiring hospitalization or treatment with intravenous anti-infectives within 30 days or oral anti-infectives within 14 days prior to the Baseline visit. * Patient has received any live attenuated vaccine 28 days or less before baseline. * Patient with hepatitis B or hepatitis C viral infection. * Patient with any of the following: hemoglobin = 10 g/L, white blood cell count = 3.0 X 109/L, platelet count =130 X 109/L, ALT = 2 times the upper limit of normal, AST = 2 times the upper normal limit, total bilirubin = 2 times the upper normal limit or creatinine = 150 umol/L. * Patient is currently using or plans to use anti-retroviral therapy at any time during the study. * Patient is known to have immune deficiency or is immunocompromised. * Female patient who is pregnant or breast-feeding or considering becoming pregnant during the study or for 150 days after the last dose of study medication. * Patient has a history of clinically significant drug or alcohol abuse in the last year. * Patient is considered by the investigator, for any reason, to be an unsuitable candidate for the study.