AIN457 Regimen Finding Study in Patients With Moderate to Severe Psoriasis

Inclusion Criteria: * Men or women at least 18 years of age at time of consent * Chronic plaque-type psoriasis diagnosed for at least 6 months at time of randomization * At time of randomization, moderate to severe psoriasis as defined by: * PASI score of 12 or greater and * IGA score of 3 or greater and * Body Surface Area (BSA) affected by plaque-type psoriasis of 10 % or greater * At screening and randomization, chronic plaque-type psoriasis considered inadequately controlled by: * topical treatment and/or * phototherapy and/or * previous systemic therapy Exclusion Criteria: * Patients meeting any of the following criteria will be excluded from entry into the study: * Forms of psoriasis other than chronic plaque-type (e.g., pustular, erythrodermic and guttate psoriasis) at screening or randomization * Drug-induced psoriasis (i.e. new onset or current exacerbation from beta-blockers, calcium channel inhibitors or lithium) and randomization * Ongoing use of prohibited psoriasis treatments (e.g., topical or systemic corticosteroids, UV therapy) at randomization. Washout periods detailed in the study protocol have to be adhered to * Ongoing use of other prohibited treatments at randomization. Washout periods detailed in the study protocol have to be adhered to. All prior concomitant medications must be on a stable dose for at least four weeks before study drug administration * Known immunosuppression (e.g., AIDS) at screening and / or randomization * History or evidence of active tuberculosis at screening. All patients will be tested for tuberculosis status using a blood test (QuantiFERON®-TB Gold In-Tube). Patients with evidence of latent tuberculosis may enter the trial after sufficient treatment has been initiated according to local regulations. * Active systemic infections (other than common cold) during the two weeks before randomization (e.g., hepatitis) * At screening, history or symptoms of malignancy of any organ system (other than history of basal cell carcinoma and / or up to three squamous cell carcinomas of the skin, if successful treatment has been performed, with no signs of recurrence; actinic keratoses, if present at screening, should be treated according to standard therapy before randomization), treated or untreated, within the past 5 years, regardless of whether there is evidence of local recurrence or metastases * History of congestive heart failure (NYHA functional classification ≥III) at screening and / or randomization * History of severe hypersensitivity to any human or humanized biological agents (antibody or soluble receptor) at screening and / or randomization * Any severe, progressive or uncontrolled medical condition at randomization that in the judgment of the investigator prevents the patient from participating in the study * Pregnant or nursing (lactating) women